THE PHYSIOLOGICAL, PATHOLOGICAL AND GENETIC BASIS OF COGNITIVE AGING AND ITS CLINICAL IMPLICATION
Han, B.X., Chinese Academy of Sciences, China
Studies on the cognitive aging from different aspects, such as neuroimaging (entorhinal cortex-ERC volume reduction, Du, et al, 2001; Sensory cortical interactions, Golob, et al, 2001), genetic marker (ApoE4 and others, Nilsson, et al, 1999), cerebrospinal fluid (CSF-A beta vs. CSF-tau, Maruyama et al, 2001), and behavioral (eyeblink clinical conditioning, Woodruff-Pak, 2001), have provided possible clinical indexes for evaluating cognitive performance and discriminating different stages of cognitive dysfunction (e.g., mild cognitive impairment vs. Alzheimer's Disease). Giving the successful application of neuropsychological examination (e.g., ADAS-cog) for the diagnosis and successfully stabilizing cognitive decline by medicine (e.g., galantamine, Tariot, 2001) developed for treatment, further studies are needed for early diagnosis of AD and decreasing the cost of informal caring for the patients (Langa, et al, 2001). Related issues were discussed based on the reviewing studies.